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Mikołaj Ogrodnik

PhD

Mikolaj Ogrodnik is a group leader at the LBG Senescence and Healing of Wounds. He received his PhD at the Newcastle Institute for Ageing (Newcastle upon Tyne, UK) and did his post-doctoral research at the Mayo Clinic (Rochester, MN, US). Ogrodnik’s laboratory explores a wide range of subjects including the early-onset responses of skin to injury, the mechanisms of scar formation, molecular basis of cell senescence in skin, relationship between cytoskeletal proteins and cell migration and engineering of artificial skin. For that, the laboratory utilizes methods including high-resolution histology, in vitro cell culture, transgenic and wild-type pre-clinical models of wounding and ageing, bioinformatics including single-cell RNA sequencing and tissue engineering. The aim of this research is to broaden our understanding about healing and aging of skin and to improve the lives of people with non-healing wounds. 

Selected publications

The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations

Ogrodnik M, Gladyshev VN. (2023) The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations. Nat Aging. 2023 Jul;3(7):766-775. doi: 10.1038/s43587-023-00447-5.

The p-rpS6-zone delineates wounding responses and the healing process

Ring NAR, Dworak H, Bachmann B, Barbara Schädl B, Valdivieso K, Rozmaric T, Heimel P, Fischer I, Klinaki K, Gutasi A, Schuetzenberger K, Leinfellner G, Ferguson J, Drechsler S, Mildner M, Schosserer M, Slezak P, Meyuhas O, Gruber F, Grillari J, Redl H, Ogrodnik M. (2023) The p-rpS6-zone delineates wounding responses and the healing process. Developmental Cell 2023 April; 58(11), https://doi.org/10.1016/j.devcel.2023.04.001

The role of senescence in cellular plasticity: Lessons from regeneration and development and implications for age-related diseases.

Ring NAR, Valdivieso K, Grillari J, Redl H, Ogrodnik M. The role of senescence in cellular plasticity: Lessons from regeneration and development and implications for age-related diseases. Dev Cell. 2022 May 9;57(9):1083-1101. doi: 10.1016/j.devcel.2022.04.005. Epub 2022 Apr 25. PMID: 35472291.

Promises and challenges of senolytics in skin regeneration, pathology and ageing

Pils, V., Ring, N., Valdivieso, K., Lämmermann, I., Gruber, F., Schosserer, M., … & Ogrodnik, M. (2021). Promises and challenges of senolytics in skin regeneration, pathology and ageing. Mechanisms of Ageing and Development, 200, 111588.